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Push the dose up faster than your body can adapt and you raise the odds of the exact side effects that make people stop

Dysbiosis of the gut microbiome observed in depressed patients can also be caused by treatment with some antidepressant drugs due to their antimicrobial activity [104]

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One significant finding is from the SELECT trial, which showed that long-term use of semaglutide in individuals with obesity but without diabetes led to a 20% reduction in major cardiovascular events and an average weight loss of 9.4%